Thursday, August 27, 2020

Cerebral Palsy Essay Conclusion Example For Students

Cerebral Palsy Essay Conclusion Cerebral Palsy (CP) is a term used to portray disarranges of development that outcome frominjury to the cerebrum. It is an issue of muscle coordination. The muscles themselves are not affected however the mind can't impart the proper signs important to train the muscles when to contract or unwind. Cerebral Palsy can be brought about by various issues happening in the pre-birth period, rashness, work and conveyance difficulty in the infant time frame because of hereditary or chromosomal variation from the norm to the cerebrum may not create in the run of the mill way.Some ecological factors, for example, drugs metabolic issues, and placental brokenness may likewise prompt CP. Beforehand it was imagined that most newborn children with cerebral paralysis had mind injury as a result of troubles during work and conveyance. Today just, a little segment of kids who are later analyzed to have Cp. had birth wounds or oxygen hardship during conveyance. There are three sorts of Cerebral Palsy. Spastic Cp. is the most widely recognized among kids. Kids with Spasticity will have tight or once in a while unbending muscles and can't move included appendages well. The lopsidedness and expanded muscle tone might be slight and may show up as awkwardness. Anyway this unevenness can likewise show up serious so the kid in incapable to move willfully with great control. Choreothetoid Cerebral Palsy is a term utilized when youngsters have unexpected automatic developments of the arm and legs. For individuals with this kind of Cp. controlling the furthest points to do exercises is amazingly troublesome. At that point there is blended Cp. in which an individual endures a blend of spacitiy and choreathetoid development. Most Children with Cerebral Palsy can be analyzed when they arrive at the age of eighteen months. Any forecasts for a newborn child under a half year are minimal better at that point surmises, and in any event, for youngsters more youthful then one it is hard to anticipate the example of inclusion. When the youngster is two years old the doctor can decide if the kid with Cp, has hemiplegia, dipelgia, or quadriplegia. It merits saying that a kid with Cerebral paralysis doesn't quit doing exercises once they have started them. Such lost aptitudes is called relapse and that is certifiably not a quality of Cp. On the off chance that relapse happens it is important to search for an alternate reason for the childs issue. All together for a youngster to have the option to walk, some significant occasions in engine control need to happen. A youngster must have the option to hold his head up before he can sit all alone, and must have the option to sit autonomously before he can stroll all alo ne. It is commonly expected that if a youngster isn't sitting up without anyone else by the age 4 or strolling by age 8, he will never be an autonomous walker. Be that as it may, a kid who begins to stroll by age 3 will surely keep on strolling when he is 13 years of age except if he has a confusion other then Cp. The primary inquiries generally posed by guardians after they are told there kid has cerebral paralysis are What will my kid resemble? what's more, Will he walk? With regards to desires and inquiries of what's on the horizon for a kid with Cerebral Palsy, it is imperative to keep up a mix of positive thinking and authenticity. Around one, half of all kids with Cp. have seizures. A seizure is an irregular message that may make somebody free control of their body. Kids may take extraordinary medicine to diminish their seizures. Around one Fourth to one, half of children with Cp. have some kind of learning issue. It might be a learning inability or it might be increasingly extreme learning issue like mental hindrance. Numerous kids with Cp. may require continuous treatment and gadgets, for example, wheelchair. By and large, 90% of kids will satisfy there 20s and past. Anyway youngsters with quadriplegia (influencing each of the 4 limits) and serious mental impediment have a lower endura nce rate. Administrations for the young youngster may incorporate proceeding with treatment, ordinary or custom curriculum, advising, specialized help, network combination openings, amusement and conceivable individual chaperons. A basic factor is by all accounts a strong family. Individuals are widely influenced by cerebral paralysis can in any case be exceptionally useful and autonomous. The HEALTH Resource Center, the clearinghouse on post-auxiliary instruction or people with CP, are taken a crack at schools and colleges. .u70c2a9c393d2e27697336f282c3089be , .u70c2a9c393d2e27697336f282c3089be .postImageUrl , .u70c2a9c393d2e27697336f282c3089be .focused content region { min-stature: 80px; position: relative; } .u70c2a9c393d2e27697336f282c3089be , .u70c2a9c393d2e27697336f282c3089be:hover , .u70c2a9c393d2e27697336f282c3089be:visited , .u70c2a9c393d2e27697336f282c3089be:active { border:0!important; } .u70c2a9c393d2e27697336f282c3089be .clearfix:after { content: ; show: table; clear: both; } .u70c2a9c393d2e27697336f282c3089be { show: square; progress: foundation shading 250ms; webkit-change: foundation shading 250ms; width: 100%; mistiness: 1; progress: haziness 250ms; webkit-progress: obscurity 250ms; foundation shading: #95A5A6; } .u70c2a9c393d2e27697336f282c3089be:active , .u70c2a9c393d2e27697336f282c3089be:hover { darkness: 1; change: murkiness 250ms; webkit-change: obscurity 250ms; foundation shading: #2C3E50; } .u70c2a9c393d2e27697336f282c3089be .focused content region { width: 100%; position: relativ e; } .u70c2a9c393d2e27697336f282c3089be .ctaText { fringe base: 0 strong #fff; shading: #2980B9; text dimension: 16px; textual style weight: intense; edge: 0; cushioning: 0; text-improvement: underline; } .u70c2a9c393d2e27697336f282c3089be .postTitle { shading: #FFFFFF; text dimension: 16px; textual style weight: 600; edge: 0; cushioning: 0; width: 100%; } .u70c2a9c393d2e27697336f282c3089be .ctaButton { foundation shading: #7F8C8D!important; shading: #2980B9; outskirt: none; fringe span: 3px; box-shadow: none; text dimension: 14px; text style weight: striking; line-tallness: 26px; moz-outskirt sweep: 3px; text-adjust: focus; text-embellishment: none; text-shadow: none; width: 80px; min-stature: 80px; foundation: url( arrow.png)no-rehash; position: outright; right: 0; top: 0; } .u70c2a9c393d2e27697336f282c3089be:hover .ctaButton { foundation shading: #34495E!important; } .u70c2a9c393d2 e27697336f282c3089be .focused content { show: table; stature: 80px; cushioning left: 18px; top: 0; } .u70c2a9c393d2e27697336f282c3089be-content { show: table-cell; edge: 0; cushioning: 0; cushioning right: 108px; position: relative; vertical-adjust: center; width: 100%; } .u70c2a9c393d2e27697336f282c3089be:after { content: ; show: square; clear: both; } READ: The authorization of maryjane EssayThere are expanding number of measures that can be taken pre-birth to lessen dangers of cerebral paralysis. The best guidance is to get clinical consideration when you realize you are pregnant. Controlling diabetes sickliness, hypertension, and dietary inadequacies during pregnancy will help forestall a few cases or rashly which can decrease the opportunity of Cp. There is no remedy for Cerebral paralysis yet. Significant advances have occurred over the most recent 15 years, which have had an extraordinary effect on long haul prosperity of youngsters brought into the world with Cp. Trend setting innovation, including PCs and designing gadgets has been applied to the necessities of people with Cerebral paralysis. Mechanical advancements have been created in the regions of discourse and correspondence, self-care and adjusting living courses of action and work destinations. The future may bring applications that are considerably progressively noteworthy. Adapting to Cerebral Palsy might be troublesome. Guardians may feel frustrated, discouraged even irate from the start. A few guardians censure themselves for their childs incapacity, while a few families discover comfort in otherworldliness. Different guardians realize what they can abBibliography:

Saturday, August 22, 2020

Hemingway and Symbolism Essay -- essays papers

Hemingway and Symbolism Ernest Hemingway and Symbolism Ernest Miller Hemingway is a notable American creator who wrote in the twentieth century. He has composed a few books, for example, A Farewell to Arms, For Whom the Bell Tolls, and The Old Man and the Sea. The Sun Also Rises was done on April1, 1926 and was distributed in October of 1926. The Sun Also Rises was Hemingway's demeanor of his own life. He had changed the names of his companions and a portion of the subtleties, yet the genuine personalities of the characters were clear to anybody in Paris. The Sun Also Rises typifies the anxiety of the post-World War I age, know as the Lost Generation. This powerfully wonderful story of a gathering of American and English exiles on a stay from Paris to Pamplona speaks to an emotional advance forward for Hemingway's developing style. Including Left Bank Paris in the 1920's and severely sensible depictions of bullfighting in Spain, the story is about the colorful Lady Brett Ashley and the hapless Jake Barnes. Ernest Miller Hemingway is an American creator who has written a few books and short stories; one of his works is The Sun Also Rises. Hemingway was conceived on July 21, 1899 in Oak Park, Illinois. Hemingway was raised with the preservationist Midwestern estimations of solid religion, difficult work, physical wellness and self assurance; on the off chance that one clung to these parameters, he was educated, he would be guaranteed of achievement in whatever field he picked . As a kid, he was instructed by his dad to chase and fish. At the point when he wasn't chasing or angling his mom showed him the better purposes of music. Hemingway never had a skill for music and endured ensemble practices and cello exercises, anyway the melodic information he obtained from his mo... ...ause the infant will demolish both of their lives. Next is the character of the lady who shows complexity, and supports the characteristics of â€Å"the girl†. She is called â€Å"the woman† on the grounds that she is more established, and the peruser is to accept, more shrewd, and experienced. The â€Å"girl† discusses â€Å"having a fine time† and â€Å"trying new drinks† which shows that she is as yet youthful, carrying on with an existence of straightforwardness, encountering a ton of things, where as the lady brings these â€Å"new drinks† to the young lady. This shows the lady as develop, more established, and experienced on the grounds that she is working rather than â€Å"trying new drinks†, and â€Å"having a fine time.† She is no longer yound relaxed difficult new beverages, she is working attempting to acquire a living. She is an aberrant strong gadget of the subject in that she the contrary picture of what the young lady is. The lady further characterizes the representative characteristics of the young lady, at the end of the day.

Friday, August 21, 2020

Extremely Creative Websites BEST Designs and Layouts to LOVE!

Extremely Creative Websites BEST Designs and Layouts to LOVE! Last Updated on March 17, 2020website created using perfect typography and color schemes? Perhaps a minimalist wonder or striking imagery spring to mind?Theyre all creative web designs, in truth, but what are the principles and ideas that make them so? Is it the art? Is it the color? Is it the layouts? Its a bit of everything, and making your own creative website will require you to gather design inspiration and mix together what catches your imagination. Disclosure As an independent review site, we get compensated if you purchase through the referral links or coupon codes on this page â€" at no additional cost to you. Dismiss alert At the least, you should be able to identify what makes the good sites so good, so lets begin.Table of Contents Elements of creative websites1. Line2. Shape3. Color4. Space5. Texture6. Typography7. Harmony8. Balance Save 9. Hierarchy10. The vertical scroll11. Flat design material design12. Card layouts13. Hero images14. Dynamic storytelling15. Hamburge r menus16. JavaScript17. Carousels18. Load screensWebsite design conclusionElements of creative websitesThe most creative website designs have something in common. They base themselves on the fundamentals of good graphic design know-how. This means working with elements like:1. LineAny two connected points. Lines can divide a space or draw attention to certain elements on a page.2. ShapeA two (or three) dimensional area that segregates itself from the surrounding space. This is often done by means of a boundary, created by lines. You can also create shapes with variances in color, texture, or value.3. ColorHues, shades, tints, and the like. Color is how we see the world. Used properly, you can use it to create order or chaos. Join the FREE TrainingDo You Want To Learn How To Build 6 Figures Authority Sites?Join This Free Training To...Finally have a proven method to finding profitable nichesGet access to a foolproof keyword research methodLearn how to outsource quality contentLearn how to build white hat links to your site without headaches 4. SpaceThis is the area in which designers work. Space can be positive, meaning something is filling it, or negative, when it is blank. Knowing what parts of the layout to leave alone and which to work in is a hallmark of creative websites.5. TextureThe way something feels. In visual design, it is the way something appears to feel. Designers can create the illusion of texture with all manner of visual trickery.6. TypographyThe written words and their appearance. Different typefaces, or fonts, can evoke different feelings.Designers balance these elements with tried-and-true concepts like:7. HarmonyA sense of unity or agreement between the elements of a design.8. BalanceThe state of equalized tension. Balanced designs arent always symmetrical. They can be chaotic in a way that draws attention to one element and away from another.Flat design is the concept of stripping all visuals down to a very basic level. A flat kind of imagery that loads quickly and looks great on all devices. No textures, no shadows, nothing that will compromise the essence of a particular element.Material design is an attempt to reintegrate some of those basic print elements. You might mistake it for flat design at first glance, but its a different beast. It allows for stylistic choices beyond the threadbare essentials flat design enforces.Many creative websites make use of one of the two options. Expect to see plenty of both when perusing through the best of the best.12. Card layoutsBye-bye, tables. Move over, tiles. Card layouts have hit the scene in a big way. Taking cues from Pinterest, cards mimic the apps standout feature and add some depth. They are interactive. They support hover effects. They turn imagery into a more integral website feature than ever before.13. Hero images14. Dynamic storytellingThe work of a masterful designer. This is a tale woven with a combination of graphics and clever text. Its a feature that wo rks best in the digital sphere, as designers have come to learn.Not all supposedly creative website ideas are award winners, though. There are some trends designers dont agree work. Stuff like:15. Hamburger menusThose three lines that you intuitively know will expose a sites options. The argument has swayed from favoring these features to disparaging them. Many designers feel that the hamburger menu is cliche, and slows visitors down but they can be useful to display a list of important pages on your website.16. JavaScriptIt might add pizazz to a site, but JS in the source code also slows the site down. Many designers are shying away from JavaScript to avoid the clutter. Keeping a site clean also improves user experience and SEO, which should be a primary goal, especially for any marketing agency that is involved in creating a theme for a site that wants to make sales.17. CarouselsTheres an argument that carousels are useful. Some think it adds visual interest and keeps the site cle an. Others feel it makes a sites content hard to access. Detractors also note that Carousels drag down SEO and site performance.18. Load screensEven the most impressively executed load screens have no place on creative websites. The design should focus on making the users experience as simple as possible. Confusing them with a tedious load screen runs counter to this goal.Example of the best creative website designsWhich sites pull it off the best? We mentioned several already, but theres room for one more SOTD (Site of the day):navigation is a cinch. Kudos, it makes him look good outside of the studio too! The designer deserves an award: visit website.Website design conclusionThere are plenty of great websites on the net to inspire you. When creating yours, make sure to respect the rules that have guided designers for years. Make your site clean, make navigation enjoyable for users, and make sure it draws in your visitors! And if you really want to stay current on web design, consi der a visit to the Awwwards:

Monday, May 25, 2020

Solute Definition and Examples in Chemistry

A solute is defined as the substance that is dissolved in a solution. For solutions of fluids, the solvent is present in greater amount than the solute. Concentration is a measurement of the amount of solute present in a chemical solution, with respect to the amount of solvent. Examples of Solutes Usually, a solute is a solid that is dissolved into a liquid. An everyday example of a solute is  salt in water. Salt is the solute that dissolves in water, the solvent, to form a saline solution. On the other hand, water vapor is considered a solute in air because nitrogen and oxygen are present in much larger concentration levels in the gas. Different Types of Solutes When two liquids are mixed to form a solution, the solute is the species present in the smaller ratio. For example, in a 1 M sulfuric acid solution, sulfuric acid is the solute while water is the solvent. The terms solute and solvent can also be applied to alloys and solid solutions. Carbon may be considered a solute in steel, for example.

Thursday, May 14, 2020

The Setting for Williams A Streetcar Named Desire

The setting for A Streetcar Named Desire is a modest, two-room flat in New Orleans. This simple set is viewed by the various characters in sharply contrasting ways—ways that directly reflect the dynamics of the characters. This clash of views speaks to the heart of the plot of this popular play. An Overview of the Setting A Streetcar Named Desire, written by Tennessee Williams is set in the French Quarter of New Orleans. The year is 1947—the same year in which the play was written. All of the action of A Streetcar Named Desire takes place on the first floor of a two-bedroom apartment.The set is designed so that the audience can also see outside and observe characters on the street. Blanches View of New Orleans Theres a classic episode of The Simpsons in which Marge Simpson lands the role of Blanche DuBois in a musical version of A Streetcar Named Desire. During the opening number, the Springfield cast sings: New Orleans!Stinking, rotten, vomiting, vile!New Orleans!Putrid, brackish, maggoty, foul!New Orleans!Crummy, lousy, rancid, and rank! After the show aired, the Simpsons producers received a lot of complaints from Louisiana citizens. They were highly offended by the disparaging lyrics. Of course, the character of Blanche DuBois, the faded Southern belle without a dime, would completely agree with the cruel, satirical lyrics. To her, New Orleans, the setting of A Streetcar Named Desire,  represents the ugliness of reality. To Blanche, the crude people that live on the street called Elysian Fields represent the decline of civilized culture. Blanche, the tragic protagonist of Tennessee Williams play, grew up on a plantation called Belle Reve (a French phrase meaning beautiful dream). Throughout her childhood, Blanche was accustomed to gentility and wealth. As the estates wealth evaporated and her loved ones died off, Blanche held on to fantasies and delusions. Fantasies and delusions, however, are very difficult to cling to in the basic two-room apartment of her sister Stella, and specifically in the company of Stellas domineering and brutal husband, Stanley Kowalski. The Two-Room Flat A Streetcar Named Desire takes place two years after the end of World War II. The entire play is staged in the cramped flat in a particularly low-income area of the French Quarter. Stella, Blanches sister, has left her life at Belle Reve in exchange for the exciting, passionate (and sometimes violent) world that her husband Stanley has to offer. Stanley Kowalski thinks of his small apartment as his kingdom. During the day, he works in a factory. At night he enjoys bowling, playing poker with his buddies, or making love to Stella. He sees Blanche as an intruder to his environment. Blanche occupies the room adjacent to theirs—so close that it impinges on their privacy. Her garments are strewn about the furniture. She adorns lights with paper lanterns to soften their glare. She hopes to soften the light in order to look younger; she also hopes to create a sense of magic and charm within the apartment. However, Stanley does not want her fantasy world to encroach upon his domain. In the play, the tightly-squeezed setting is a key factor in the drama: It provides instant conflict. Art and Cultural Diversity in the French Quarter Williams offers multiple perspectives on the plays setting. In the plays beginning, two minor female characters are chatting. One woman is black, the other white. The ease with which they communicate demonstrates the casual acceptance of diversity in the French Quarter. Williams is presenting here a view of the neighborhood as having a thriving, exuberant atmosphere, one that nurtures an open-minded sense of community. In the low-income world of Stella and Stanley Kowalski, racial segregation appears to be nonexistent, a sharp contrast to the elitist realms of the old South (and Blanche Dubois childhood). As sympathetic, or pathetic, as Blanche may appear throughout the play, she often says intolerant remarks about class, sexuality (in the case of her homosexual husband who was devastated by her negative comments), and ethnicity. In fact, in an ironic moment of dignity (given his brutality in other contexts), Stanley insists that Blanche refer to him as an American (or at least Polish-American) rather than use the derogatory term: Polack. Blanches refined and disappeared world was one of brutal racism and denigration. The beautiful, refined world she longs for never existed. In the present as well, Blanche maintains this blindness. For all of Blanches preaching about poetry and art, she cannot see the beauty of the jazz and blues which permeate her present setting. She is trapped in a so-called refined, yet racist past and Williams, highlighting the contrast to that past, celebrates the uniquely American art form, the music of the blues. He uses it to provide transitions for many of the plays scenes. This music can be seen to represent the change and hope in the new world, but it goes unnoticed to Blanches ears. Belle Reves style of aristocracy has died away and its art and genteel customs are no longer relevant to Kowalskis post-war America. Gender Roles After World War II The war brought innumerable changes to American society. Millions of men traveled overseas to face the Axis powers, while millions of women joined the workforce and the war effort at home. Many women discovered for the first time their independence and tenacity. After the war, most of the men returned to their jobs. Most of the women, often reluctantly, returned to the roles as homemakers. The home itself became the site of a new clash. This post-war tension between the roles of the sexes is another, very subtle thread in the conflict in the play. Stanley wants to dominate his home in the same way males had dominated American society before the war. While the main female characters in Streetcar, Blanche and Stella, are not women who are seeking the socio-economic independence of the workplace, they are women who had money in their youth and, to that degree, were not subservient. This theme is most evident in Stanleys well-known quote from Scene 8: What do you think you are? A pair of queens? Now just remember what Huey Long said—that every mans a king—and Im the King around here, and dont you forget it. Contemporary audiences of Streetcar would have recognized, in Stanley, the male side of what was a new society-wide tension. The modest two-room flat that Blanche disdains is this working mans kingdom and he will rule. Stanleys exaggerated drive for domination indeed extends, at the end of the play, to the most extreme form of domination, rape.

Wednesday, May 6, 2020

To Encourage Healthy Eating, Higher Taxes Should Be...

To encourage healthy eating, higher taxes should be imposed on soft drinks and junk food. Do you agree or disagree. Nowadays is getting more and more important to stay fit and healthy. There are a lot of negotiations about how to prevent junk food market. One of many possible solutions could be to impose higher taxes on soft drinks and junk food, what could encourage healthy eating. Although, from first sight, it can look like a good solution, but in this essay I am going to prove, that high taxes is not the best way, event, in my opinion, junk food must be replaced by healthy and home-made food. Firs of all, in many countries the high cost of eating healthy food is often just an excuse for being overweight, especially by†¦show more content†¦Several research studies have found that junk food can affect the brain almost the same way as nicotine or heroin. People get addicted to eating out, but they do not have to eat out because it is cheaper. That is why, in my opinion, imposing higher taxes on junk food would not prevent consumption of fast food and, even more, encourage healthy eating. People should, firstly, began to look after themselves, for example, eat a wide variety of nutrient-rich foods, do not starve themselves, maintain a healthy body weight, learn how to cook healthily, when dining out avoid fast food restaurants, eat regular meals, eat enough calories, but do not over eat, drink more water and, I think, the most important thing is to start moving. As it was said â€Å"eat to live, do not live to eat† and use the money you have left over to enjoy your life away from the table. To sum up, it is obvious, that no matter what a person tries to do, there is no way to prevent a consumption of soft drinks and junk food. Fast food impacts people brain and get them addicted to it and imposing higher taxes is not a solution. 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Tuesday, May 5, 2020

Climate Change and Food

Question: Discuss about theClimate Change and Food. Answer: Key Principles about Public Health, Climate Change and Food Quality and Security of Food and Climate Change Climate change will influence the quality of food existing for use by individuals.Transformed environment for food manufacture may end in rising pathogens, fresh harvest and cattle species, and changed use of insecticides and veterinary medications, and influence the chief transmit systems via which contaminants travel from the atmosphere into foodstuff. Climate change lessening may amplify expenditure of foods whose manufacture lessens greenhouse gas emanations. Framework Figure 1. The planning cycle The steps in short are: recognize the determinants of the fitness crisis, their operational conditions and the populace groups affected measure the hazards and profit to recognize what must be tackled spot intercession options and evaluate them choose the portfolio of intercession that can tackle the crisis employ the portfolio assess the portfolio (2) Security of Food There are three key mechanism of food safety: Food access: the capacity to obtain and eat healthy food Food availability: delivery of foodstuff inside a neighbourhood upsetting food security of persons, families or a complete populace Food use: the correct utilization of food depending on awareness of fundamental nutrition and care Key Principles about Public Hhealth, Climate Change and Water Quality and Security of Water Key Issues Figure 2 The quality and security of water is threatened by The risk of contamination from microbial pathogens and chemicals Depletion in supply Waterborne diseases Privatization Oceanic stress Quality and Security of Water, Specific to Climate Change Climate changehas numerous consequences on water on a large scale. Thawing of glacial ice into the sea Increase in atmospheric water, resulting inmore, heavy rainfall Warm air swaps snow with precipitation and evaporation rates swell. Thawing of inland glaciers In sub-tropics, there happens reduction in precipitation in already arid regions. Further severe floods and famine worldwide Shifting weather and rising temperatures ensuing increased waterborne disease spreading Difference The two approaches illustrate the blow to public health by the risks of decreased water quality and security. However, the second one stresses that weather change is a chief supplier to this risk. It might alter the locus of the mitigation policies that are created and applied in reducing climate change. Climate Change Public Health and Public Health Climate change, jointly with other natural and man-made health issues, manipulate public health and ailments in several ways. Some active health risks will strengthen and newer ones will materialize. Not everybody is uniformly in danger. Important factors comprise age, economic assets, and geography. Public health is normally influenced by disorders of physical, organic, and environmental system, counting disorder beginning here and elsewhere. The health outcomes of these disorders contain amplified respiratory and cardiac ailment, injuries and sudden deaths associated to severe weather situations, alterations in the occurrence and geographical allocation of food- plus water-borne diseases and other communicable diseases, and risks to psychological health (1). References CDC - Climate Change and Public Health - Climate Effects on Health [Internet]. 2016. Available from: [Internet]. 2016 Available from: